Sex differences in recombination

Sex differences in recombination

One of the stronger empirical generalizations to emerge from the study of genetic systems is that achiasmate meiosis, which has evolved 25-30 times, is always restricted to the heterogametic sex in dioecious species. usually the male. Here we collate data on quantitative sex differences in chiasma frequency from 54 species (4 hermaphroditic flatworms, 18 dioecious insects and vertebrates and 32...

Crossover interference underlies sex differences in recombination rates.

In many organisms, recombination rates differ between the two sexes. Here we show that in mice, this is because of a shorter genomic interference distance in females than in males, measured in Mb. However, the interference distance is the same in terms of bivalent length. We propose a model in which the interference distance in the two sexes reflects the compaction of chromosomes at the pachyte...

The two-locus model with sex differences in recombination.

The criteria for stability of the equilibrium with D=0 are obtained for the two locus model with multiplicative or symmetric fitnesses when the recombination values in males and females are different. It is shown that if r is defined to be equal to the average of the recombination values in males and females, then the criteria are exactly the same as in the standard two locus model.-The equilib...

Why sex and recombination?

Sex and recombination have long been seen as adaptations that facilitate natural selection by generating favorable variations. If recombination is to aid selection, there must be negative linkage disequilibria-favorable alleles must be found together less often than expected by chance. These negative linkage disequilibria can be generated directly by selection, but this must involve negative ep...

sex differences in acute myocardial infarction